Chemical characteristics of 99mTc-labeled amine oximes

Abstract

A series of alkylene amine oximes including En(AO) 2, Pn(AO) 2, DmPn(AO) 2, HMPAO, Bn(AO) 2 and Pent(AO) 2 were synthesized and complexations of the amine oximes with a trace-level of 99mTcO 4 − were undertaken in the presence of Sn 2+. The 99mTc-amine oxime complexes obtained were characterized simultaneously by solvent extraction, TLC, electrophoresis and HPLC. The labeling yield, neutrality, lipophilicity and stability of the 99mTc-amine oxime complexes were sufficiently investigated. According to the structures found by x-ray diffraction in previous literature, the complexes of 99Tc with the ligands with 2-C and 3-C backbones [including En(AO) 2, Pn(AO) 2, DmPn(AO) 2 and HMPAO in the present work] are in the form of TcOL, where L is the ligand involved, whereas those with 4-C and 5-C backbones [including Bn(AO) 2 and Pent(AO) 2] are in the form of TcO 2L. The chemical behaviors of the complex of no-carrier-added 99mTc with the ligands found in observed study correlate with the TcOL-type and the TcO 2L-type structures aforementioned.