Characterizing interstitial lung disease among patients with psoriasis: A cross-sectional analysis in the NIH All of Us Research Program.

Abstract

In this study, we utilized a case-control design investigating electronic health record (EHR) data of 156,707 participants from the National Institutes of Health’s All of Us Research Program to evaluate the association between psoriasis and interstitial lung disease (ILD). We demonstrated that the rate of ILD was significantly higher among those with psoriasis than controls (4.5% vs. 2.2%; P < 0.001). Furthermore, using three multivariable models controlling for several confounding variables, we demonstrated a consistent significant association between psoriasis and ILD with the most stringent model demonstrating an OR of 1.20 (95% CI: 1.04–1.39; P = 0.014).