Characterized and synthesis of chitosan nanoparticle as nanocarrier system technology

Abstract

Chitosan is a natural material produced by deacetylation of chitin from crustacean exoskeleton. Being biocompatible, biodegradable, and affordable, chitosan is widely explored in biomedical field as active agent or drug carrier. Nanoparticles with its unique physicochemical properties, have great potential to maximize therapeutic efficacy. This study used chitosan nanoparticles made by ionotrophic gelation technique. The aim of this study was to characterized chitosan nanoparticles for particle size, surface morphology and degree of deacetylation. The chitosan nanoparticles diameter size was 48nm with polydispersity index was 0,289 and degree of deacetylation less than 75%. Therefore, chitosan nanoparticle is a promising nanocarrier system for drug delivery to enhance drug permeation.