Abstract
When a strain of Escherichia coli with relaxed amino acid control overproduces RNA, the material made consists of 23-S, 16-S and 4-8-S RNA. When the overproduction occurs in the absence of protein synthesis, as following a shift down from amino acids to minimal medium, the pattern of accumulation is similar to that observed with normal cells inhibited by chloramphenicol. The 23-S and 16-S RNA are present as abnormal ribosomes, and proportionally less of these elements are formed than of s-RNA. At least part of the s-RNA appears to have amino acid accepting activity. When the overproduction occurs with some concomitant protein synthesis, as during adenosine inhibition, then the accumulated RNA appears as apparently normal 50-S, 30-S and soluble components in normal proportions. From these results it has been concluded that the single RC locus affects the normal synthesis of both ribosomal and soluble RNA during amino acid restriction.
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