Abstract
The aim of this study was to evaluate the effect of scaffolds native or polyanionic collagen matrix (submitted to alkaline treatment for 48 or 96 hours, PCM48 or PCM96, respectively) on the repair of osteoporosis bone fractures resulting from the gonadal hormone alterations caused by ovariectomy in rats undergoing hormone replacement therapy. The physical and mechanical characteristics of bone were analyzed. Macroscopic analysis revealed the absence of pathological alterations in the implanted areas. The percent mineral matter and bone mineral density of the femurs were lower in ovariectomized rats. The mechanical strength of newly formed bone was greater in the area receiving the PCM96 scaffolds compared to the area implanted with the native scaffolds. The PCM96 scaffold is the best choice for bone repair in animals with hormone deficiency since it promotes faster bone growth and good mechanical strength.
Highlights
The ovary is an endocrine gland responsible for the production of estrogen and progesterone
There are no data in the literature showing the possible effects of osteoporosis or hormone replacement therapy on bone-implant interactions[9]. In view of this fact and of the advantages offered by artificial collagen matrices, the objective of the present study was to evaluate the volume density of newly formed bone at the implant site and the mechanical strength and physical properties of femoral defects filled with polyanionic collagen scaffolds in rats with ovariectomyinduced osteoporosis
The animals were divided into the following groups: group 1, non-ovariectomized animals (NO); group 2, unilaterally ovariectomized animals (UO); group 3, bilaterally ovariectomized animals not submitted to hormone replacement therapy (BOWHRT); group 4, bilaterally ovariectomized animals submitted to hormone replacement therapy (BOHRT)
Summary
The ovary is an endocrine gland responsible for the production of estrogen and progesterone. A decrease in estrogen secretion is observed in cases of early menopause, late menarche[1,2] and ovariectomy[3]. Deficiency in this hormone results in uncontrolled bone remodeling characterized by a decrease in osteoblastic activity and in bone matrix and reduced deposition of calcium and phosphorus in bone. These alterations can damage bone microarchitecture, predisposing to the occurrence of osteoporosis[1,2]. Pathological fractures are generally treated surgically by placement of a total prosthesis or by fixation with pins/screws depending on the type and severity of the fractures[4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
