Abstract
The intermediate-conductance calcium-dependent potassium channel (KCa3.1) is functional in the inner mitochondrial membrane (IMM) of various cancer cell lines, as demonstrated by patch-clamp and Western Blot. Decreased expression of KCa3.1 was found to affect oxidative phosphorylation and ATP production (Kovalenko et al., 2016) suggesting a role in fine-tuning mitochondrial energy metabolism, but its precise role in the IMM has not been elucidated so far. Here we report the synthesis and characterization of a mitochondria-targeted derivative of a high-affinity KCa3.1 antagonist.
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