Abstract
Cytogenetic and molecular cytogenetic investigations from bone marrow samples were performed in 83 patients with multiple myeloma. Karyotype analyses were made after cultivation with and without growth factors. The polyploidy level ranged from 3n to 6n. For each patient the composite karyotype was delineated. The number of abnormalities per aberrant cell was in a range from 1 to 17 (x =3,7). The comparison of CGH and FISH results showed an accordance of 92%. In total, 57% of cells showed chromosomal aberrations.
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