Abstract
Abstract Semaphorins are a family of membrane-bound and secreted signaling molecules with active roles in nearly every organ system in processes ranging from heart morphogenesis to tumor development. We are investigating the potential roles of these molecules during T cell development in the thymus. Using Real Time PCR, we have characterized the mRNA expression of Sema4D and Sema7A, semaphorins with known peripheral immune system activity, in subsets of developing thymocytes. While Sema4D and Sema7A mRNA is expressed by all subsets of thymocytes, there appears to be no differential expression of these transcripts between CD4-CD8-, CD4+CD8+, CD4+, and CD8+ populations. While Sema7A expression has previously been described in the human thymus, this is the first time Sema4D and Sema7A mRNA expression has been reported in the murine thymus.
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