Abstract
Titin, the giant sarcomere protein, consists of multiple domains and regions of repeated structural elements that are essential for sarcomeric integrity of the myofibril. The N2A region is located at the junction between the proximal tandem Ig region and the PEVK region and is comprised of four Ig domains and a unique 117 amino acid insertion sequence (N2A-IS). The insertion sequence resides between the Ig80 and Ig81 domains, and exists in skeletal muscle, as well as the N2AB isoform of cardiac muscle.An analysis of the insertion region sequence revealed a putative binding site for the calcium-binding protein S100A1, which we have been characterizing.
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