Characterization of nanoemulsion gotukola, mangosteen rind, cucumber and tomato extract for cosmetic raw material

Abstract

Agingis related to defacement caused by free radical and the most common signs are fine lines and wrinkles. Wrinkles occur in skin layer called dermis-contained collagen that is responsible in preventing wrinkles. This physiological change on skin made an individual look old, and this is a troubling issue especially for women. Natural substances have an excellent anti-aging remedy to improve skin defection caused by free radical and maintain skin rejuvenation. Itis already proved that gotukola, mangosteen rind, cucumber and tomato extract has antioxidant activity. In this study, these extracts were formulated in nanoemulsion which was prepared in anti-aging topical preparation. This nanoemulsion system was expected to accelerate active agent absorption into skin tissue. It was also investigated the the emulsion stability system by pH, refractive index, viscosity and particle size parameter. It was shown that the anti-aging topical preparation with a composition of 2% Gotukola extract, 2% mangosteen rind extract, 2 % tomato extract and 4% cucumber extract was stable for 2 months of observation with average pH 6.16 ± 0.33; 6.11 ± 0.351, refractive index 1.38817 ± 0.00863; 1.37 ± 0.00453, viscosity 3148 cP ± 1068; 1638 cP ± 1294 and particle size 1.14 μm ± 0.84; 1.64 μm ± 0.99 in 5 °C and ambient temperature respectively. Overall, the emulsion system was relatively stable in both storage temperature 5 °C and ambient temperature. It was also proven to be safe for human application.