Abstract
Metabolites isolated from human urine after oral administration of dimethisterone (6α-methyl-17α-(1-propynyl)-17β-hydroxy-4-androsten-3-one) and norethisterone (17α-ethynyl-17β-hydroxy-4-estren-3-one) were identified by gas chromatography and mass spectrometry. The major metabolite of dimethisterone is 6α-methyl-17α-(1-propynyl)-5β-androstane-3α, 17β-diol. The major urinary metabolites of norethisterone are 17α-ethynyl-5β-estrane-3α, 17β-diol and 17α-ethynyl-5α-estrane-3α, 17β-diol. The drug metabolites can be readily differentiated from urinary metabolites of endogenous steroids by both gas Chromatographic retention data and mass spectrometry.
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