Abstract
Objectives. This paper presents data on the development and study of the structural properties of iron-doped crystalline silicon (nc-Si/SiOx/Fe) nanoparticles obtained using the plasma-chemical method for application in magnetic resonance imaging diagnostics and treatment of oncological diseases. This work aimed to use a variety of analytical methods to study the structural properties of nc-Si/SiOx/Fe and their colloidal stabilization with citrate anions for in vivo applications.Methods. Silicon nanoparticles obtained via the plasma-chemical synthesis method were characterized by laser spark emission spectroscopy, atomic emission spectroscopy, Fouriertransform infrared spectroscopy, and X-ray photoelectron spectroscopy. The hydrodynamic diameter of the nanoparticles was estimated using dynamic light scattering. The toxicity of the nanoparticles was investigated using a colorimetric MTT test for the cell metabolic activity. Elemental iron with different Fe/Si atomic ratios was added to the feedstock during loading.Results. The particles were shown to have a large silicon core covered by a relatively thin layer of intermediate oxides (interface) and an amorphous oxide shell, which is silicon oxide with different oxidation states SiOx (0 ≤ x ≤ 2). The samples had an iron content of 0.8–1.8 at %. Colloidal solutions of the nanoparticles stabilized by citrate anions were obtained and characterized. According to the analysis of the cytotoxicity of the modified nanosilicon particles using monoclonal K562 human erythroleukemia cells, no toxicity was found for cells in culture at particle concentrations of up to 5 µg/mL.Conclusions. Since the obtained modified particles are nontoxic, they can be used in in vivo theranostic applications.
Highlights
НАУЧНАЯ СТАТЬЯХарактеризация наночастиц кристаллического кремния, легированного железом, и их модификация цитрат-анионами для использования in vivo
This paper presents data on the development and study of the structural properties of iron-doped crystalline silicon nanoparticles obtained using the plasma-chemical method for application in magnetic resonance imaging diagnostics and treatment of oncological diseases
This work aimed to use a variety of analytical methods to study the structural properties of nc-Si/SiOx/Fe and their colloidal stabilization with citrate anions for in vivo applications
Summary
Характеризация наночастиц кристаллического кремния, легированного железом, и их модификация цитрат-анионами для использования in vivo. В работе приводятся данные по разработке и изучению структурных свойств полученных плазмохимическим методом наночастиц кремния nc-Si/SiOx/Fe, легированных железом. Цель работы – исследование свойств наночастиц кремния, легированных железом, комплексом аналитических методов и их стабилизация цитрат-анионами для применения в диагностике методом магнитно-резонансной томографии и лечении онкологических заболеваний. Наночастицы кремния, полученные плазмохимическим методом синтеза, были охарактеризованы лазерно-искровым эмиссионным методом, методом атомной эмиссионной спектроскопии, Фурье-ИК-спектроскопией, рентгеновской фотоэлектронной спектроскопией. %. Были получены и охарактеризованы коллоидные растворы наночастиц, стабилизированные цитрат-анионами. Ключевые слова: наночастицы кремния, железо, цитрат-анионы, рентгеновская фотоэлектронная спектроскопия, Фурье-инфракрасная спектроскопия, цитотоксичность. Для цитирования: Рожков К.И., Ягудаева Е.Ю, Сизова С.В., Лазов М.А., Смирнова Е.В., Зубов В.П., Ищенко А.А.
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