Abstract
Light chain amyloidosis (AL) is one of the most common systemic amyloidosis. It is caused by the light chain variable domain over expression at the plasmatic cells. The excess of light chains induces self-association and fibrillar aggregates, which are extracellularly deposited in tissues and organs, such as liver, heart, and kidneys. The deposition of the light chains cause organ failure and eventually death. However, the fibrillar aggregation mechanism remains poorly understood. Light chains are classified into kappa (κ) and lambda (λ) families.
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