Abstract
Inhaled corticosteroids (ICS) remain gold standard asthma therapy; however, some patients appear to require chronic systemic corticosteroids (SCSs) for optimal control. Although no previous studies have addressed factors predisposing a severe asthmatic patient to require SCSs, obesity, persistent inflammation and airway obstruction have all been associated with higher inhaled and SCS use.(1, 2) The study's purpose was to identify factors, which could increase the likelihood for chronic SCS use in adults with severe asthma (SA) from the Severe Asthma Research Program (SARP) to help identify high-risk patients. Biologic and clinical factors were compared between rigorously defined SA participants who used SCSs regularly verses those who did not. Logistic regression analysis identified the most predictive factors.
Accepted Version (
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Published Version
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