Characterization of Drug Delivery Particles in Pharmaceutical Disperse Systems: A Review

Abstract

This review focuses on micromerties which is the science and technology of small particles. Pharmaceutical particle and powder characterization is key to pharmaceutical manufacturing processes and products as they often involve bulk powders in pharmaceutical dispersed systems. Particle size and powder properties will influence physical properties, such as the flowability of a powder, and in turn, will impact processing, blending, dissolution, delivery and bioavailability. Moreover, the appropriate selection of methods and particle engineering technologies of their production, characterization, are critical issues need considerations. Furthermore, optimization of their production process along with the drug/excipient particles, can provide insight understanding of their in vivo behaviour. In particular, characterization techniques for particle size distribution and morphology, drug loading structure of matrix components, porosity, particle surface chemistry, surface charge, are discussed in this review.