Abstract
Background: Unfortunately, the majority of patients with colorectal cancer liver metastases (CRCLM) experience disease recurrence following hepatic surgery. The key challenge is therefore optimal patient selection, which currently relies on anatomical and clinical parameters. Exploring a potential molecular signature may be predictive for seeing a clinical benefit from CRCLM resection. Methods: Consecutive patients who underwent CRCLM resection at our medical center between 2006 and 2016 were divided into cohorts of “good prognosis” (GP) or “poor prognosis” (PP) based on the time interval between their resection and disease recurrence. Proteomic analysis was performed on the surgical specimen and correlation analysis was carried out with demographics and clinical outcomes. Results: Proteomic analysis revealed 99 differentially expressed proteins of which a third were associated with extracellular matrix (ECM) pathways as the matrix metalloproteinases (MMPs). Multivariate analysis yielded a statistically differential proteomic pattern between the cohort regardless of perioperative treatment. Conclusion: Our results indicate a different proteomic landscape in the cohort of patients who had a clinical benefit from CRCLM resection which appears to be correlated with ECM pathways. Further prospective studies are needed to define the role of ECM pathways in prognostics and patient selection for surgical procedures for CRCLM.
Highlights
Despite effective screening programs and comprehensive treatment, the mortality rate of colorectal cancer (CRC) remains high [1,2]
25% of CRC patients are diagnosed with colorectal cancer liver metastases (CRCLM) and are defined as having synchronous CRCLM
Consecutive patients with CRCLM who were treated at the department of surgery at Rabin Medical Center (RMC) between 2006 and 2016, and for whom formalin fixed frozen paraffin embedded (FFPE) surgical samples of liver metastases were available, were included in the study
Summary
Despite effective screening programs and comprehensive treatment, the mortality rate of colorectal cancer (CRC) remains high [1,2]. 25% of CRC patients are diagnosed with colorectal cancer liver metastases (CRCLM) and are defined as having synchronous CRCLM. Such synchronicity has been correlated with a poor prognosis [3]. For patients with limited disease, surgical resection remains the treatment of choice. The majority of patients with colorectal cancer liver metastases (CRCLM) experience disease recurrence following hepatic surgery. Conclusion: Our results indicate a different proteomic landscape in the cohort of patients who had a clinical benefit from CRCLM resection which appears to be correlated with ECM pathways.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call