Abstract
BackgroundLipofilling is a cosmetic surgical procedure that consists in the withdrawal of a small quantity of fat tissue from a suitable anatomic area and the reimplantation of this tissue in another corporeal district in the same individual, so as to obtain a filling effect. Recently, adipose-derived stem cells (ADSCs) have been isolated in the aspirates. These are pluripotent mesenchymal stem cells that are able to differentiate in mature adipose cells or other adult mesenchymal cells after paracrine or autocrine hormonal stimulations, thus favoring a longer survival of the implanted tissues.MethodsIn this article, we have defined a new method for liposuction (Prolipostem®), where the ADSCs are recovered and mixed with the suctioned adipose tissue derived from the abdominal fat, before the reimplantation.ResultsWe have demonstrated by immunocytochemistry the presence of ADSCs in the adipose tissue taken with Prolipostem® from the abdominal fat and the ability of these ADSCs to differentiate in mature adipose cells in vitro.ConclusionsThe possibility to enrich the tissue to be implanted with ADSCs would assure a longer survival of the cells implanted and a regeneration of the host tissue thanks to growth and angiogenic stimuli induced by the ADSCs.
Highlights
Lipofilling is a cosmetic surgical procedure that consists in the withdrawal of a small quantity of fat tissue from a suitable anatomic area and the reimplantation of this tissue in another corporeal district in the same individual, so as to obtain a filling effect
The possibility to enrich the tissue to be implanted with adipose-derived stem cells (ADSCs) would assure a longer survival of the cells implanted and a regeneration of the host tissue thanks to growth and angiogenic stimuli induced by the ADSCs
ADSCs are present in the adipose tissue taken with Prolipostem® It is well known that ADSCs express several markers (Zhu et al 2010)
Summary
Lipofilling is a cosmetic surgical procedure that consists in the withdrawal of a small quantity of fat tissue from a suitable anatomic area and the reimplantation of this tissue in another corporeal district in the same individual, so as to obtain a filling effect. Adipose-derived stem cells (ADSCs) have been isolated in the aspirates. The technique consists in the withdrawal of a small quantity of fat tissue from a suitable anatomic area (abdomen, sides, thighs, knees) and the reimplantation of this tissue in another corporeal district in the same individual, so as to obtain a filling effect (Joyce et al 2015; Savoia et al 2014; Savoia et al 2013). It is clear that, if the fat is injected in large quantities, not all fat cells will be in contact with vascularized tissues and they will subsequently undergo apoptosis, necrosis, and resorption
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