Abstract
3-[ 123I]Iodo-L-α-methyl tyrosine ([ 123I]IMT) scintigraphy of extracranial malignant tumors has been described, but little is known about the transport systems involved in [ 123I]IMT uptake into extracranial tumor cells. Here, the precise kinetics of [ 123I]IMT transport into human Ewing’s sarcoma cells (VH-64) was determined. The apparent Michaelis constant was of high affinity value ( K m =41.7±3.9 μM) and maximum transport velocitiy amounted to V max=20.7±0.6 nmol·mg protein −1·10 min −1. Inhibition experiments revealed the predominance of [ 123I]IMT uptake via sodium-independent system L.
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