Abstract
The radiolabelled amino acid 3-[ 123I]iodo-L-α-methyl tyrosine ([ 123I]IMT) is a promising tool for the diagnosis and monitoring of brain tumors using single-photon emission tomography (SPECT). However, little is known about the precise kinetics of [ 123I]IMT uptake in human glioma cells. The kinetic analysis of [ 123I]IMT transport in human GOS3 glioma cells yielded a high-affinity apparent Michaelis constant (K m = 20.1 ± 1.5 μM). The maximum transport velocity (V max) amounted to 34.8 ± 1.9 nmol/mg protein/10 min. Competitive inhibition experiments revealed that [ 123I]IMT transport is mediated principally by the sodium-independent system L.
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