Characterization, Biocompatibility and Biological Properties of Cissampelos pareira Pectin-Based Hydrogel Patch Containing Heliotropium indicum Extract

Abstract

Cissampelos pareira and Heliotropium indicum have been used as traditional medicine for treating several disorders. Specifically, Cissampelos pareira simply forms a gel without additional compounds which result from mainly pectin sources. In this study, the pectin from Cissampelos pareira was used to develop a hydrogel patch by adding Heliotropium indicum extract. The characterization of pectin-based hydrogel patch and pectin-based hydrogel containing Heliotropium indicum patch was evaluated. The results revealed suitable characterization of pectin-based hydrogel patches in physical and mechanical properties. The pectinbased hydrogel patches also presented biological activities through antioxidant and anti-inflammatory activities and these effects were synergized in a pectin-based hydrogel containing Heliotropium indicum patches. Furthermore, the pectin-based hydrogel patches presented biocompatibility by non-cytotoxicity to fibroblast and macrophage cells. Fibroblasts can proliferate in the pectin-based hydrogel patches. According to the results, the pectin-based hydrogel patches are of great benefit in pharmaceutical and cosmeceutical applications.