Abstract
Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.
Highlights
Polymeric biomaterials combined with natural extracts are an important line of research in the field of tissue engineering as regeneration matrices or scaffolds [1,2]
The carboxylic acid and methyl ester carboxylate groups present in these compounds confer to Aloe vera hydrogel a high polarity, which is an advantage for the practical use confer toitAloe vera hydrogel a high to polarity, which an advantage for thewith practical use because guarantees the adhesion a wound but is with good interaction proteins and growth factors [6,15,17]
The results suggest that the Aloe vera hydrogel, a fresh hydrogel enriched with isopropanediol and TEA, of Derseg Co. is competitive for improving the skin wound-healing process, even though Restauder® was used after 6 months of preparation, a period after which no decrease in its effectiveness was observed
Summary
Polymeric biomaterials combined with natural extracts are an important line of research in the field of tissue engineering as regeneration matrices or scaffolds [1,2]. Natural hydrogels stand out because of their high water content, biocompatibility, and biodegradation. Aloe-emodin, aloesin, aloin, and acemannan are some of the most studied compounds in Aloe vera, where acemannan is known to induce tissue repair [13,14,15,16,17,18]. These polysaccharides have been explored as a functional source for biomedical and pharmaceutical materials due to their natural gelling mechanism, high availability, and nontoxic nature [19,20,21,22]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
