Abstract
The v- sis oncogene of simian sarcoma virus encodes a protein which is homologous to the human platelet-derived growth factor B-chain. The biologically active v- sis protein was expressed in silkworm larvae using the Bombyx mori nuclear polyhedrosis virus vector system. The v- sis protein purified from infected silkworm larvae is a 30 kDa disulfide-linked homodimer. Mitogenic activity of the v- sis protein was comparable to that of PDGF and inhibited by the pretreatment with anti-PDGF antibody. These results show that the recombinant v- sis protein is biologically and antigenically related to PDGF.
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