Abstract
A series of 3-(2-benzylidenehydrazinyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were synthesized via a one-pot, three-component protocol. The new derivatives were purified and confirmed by their spectroscopic (FT-IR, 1H NMR, 13C NMR and Mass) and elemental analysis. Further, the synthesized compounds were screened for the binding interactions with p38MAPK (PDB id: 3BX5) by in-silico molecular docking studies. amongst the synthesized compounds 4f, 4 g, and 4k were interacted with good dock score at active site of p38MAP Kinase.
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