Abstract
Pharmacognosy Research,2021,13,4,192-198.DOI:10.5530/pres.13.4.11Published:October 2021Type:Original ArticleAuthors:Nagaraju Bandaru, D.S.N.B.K Prasanth, A.Rajasekhar Reddy, G.S.N Koteswara Rao, Kumar V.S Nemmani, and Alla Narayana Rao Author(s) affiliations:Nagaraju Bandaru1,*, D.S.N.B.K. Prasanth1, A.Rajasekhar Reddy2, G.S.N Koteswara Rao3, Kumar V.S Nemmani4 Alla Narayana Rao1 1Department of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA. 2Department of Pharmaceutical Chemistry, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA. 3Department of Pharmaceutics, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA. 4Department of Pharmacology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, INDIA. Abstract:Background: The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1). Methods: In this research Biophytum veldkampii was subjected to extraction using methanol. In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0. Results: The outcomes revealed that the methanolic extract has most prominenant anti-inflammatory activity at various doses. Among all the substances 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone revealed the most effective docking rating of -6.8, which is near to Diclofenac, i.e. - 6.9, ensuring that 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone has a strong binding fondness in between protein and ligand. Conclusion: From the results, a conclusion can be drawn that the anti-inflammatory activity of Biophytum veldkampii in both in vivo and in silico methods. This information sustains 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone to be a useful anti-inflammatory compound beneficial to future clinical studies. Keywords:2, 3’, 4’-Tetrahydroxy-2 benzylcoumaranone, 6, Autodock4.0, Carageenan, Cyclooxygenase II, In-silico, Inflammation, PhytochemicalView:PDF (1.66 MB)
Highlights
Medicinal plants are a source of valuable therapeutic assistance for the alleviation of human diseases
Background: The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1)
In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0
Summary
Medicinal plants are a source of valuable therapeutic assistance for the alleviation of human diseases. The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1). In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0. Conclusion: From the results, a conclusion can be drawn that the anti-inflammatory activity of Biophytum veldkampii in both in vivo and in silico methods. This information sustains 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone to be a useful anti- inflammatory compound beneficial to future clinical studies.
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