Abstract
Polyvinylpyrrolidone (PVP) modified silica coated with albumin as host matrices for bilirubin removal were synthesized through sol–gel method. Such materials were characterized by scanning electron microscopy, nitrogen adsorption, Fourier transform spectroscopy and elemental analysis. It was shown that PVP grafted onto silica provides strong and high immobilization of BSA in comparison with pure silica. These modified silicas with different content of BSA were used to study bilirubin adsorption from the bilirubin–phosphate solutions (pH 7.4). The effect of time, ionic strength and concentration on the bilirubin adsorption were investigated as well. The results demonstrate that the adsorption capacity of tested samples increases after surface modification. The maximum adsorption capacity for bilirubin was 2.82 mg/g.
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