Abstract
This paper reports on a pH responsive material and a mathematical model for a drug release study. This material can be applied as a tumor drug carrier, because the tumor tissue has a different pH (5.7ā7.8) compared to the healthy tissue (7.3ā7.4). Maleic anhydride (MA) is introduced into the chitosan (CTS) backbone to create a polyampholyte chitosan-graft-maleic (CgM) film that has a pH responsive property. The success of the reaction is confirmed by Fourier transform infrared spectroscopy, which shows a new peak at 1705cm-1
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