Abstract
To increase the water solubility of resveratrol (RES) and explore the possibility of solid-phase preparation technology as an alternative to traditional spray drying technology. In this study, herein, three resveratrol-stevia glycoside-hydroxypropyl-β-cyclodextrin (RES-STE-HP-β-CD) complexes were prepared by jet milling, ball milling and spray drying. The three complexes were subjected to saturation solubility determination, characterization (SEM, XRD, FT-IR and 1H NMR), antioxidant activity evaluation and in vitro cytotoxicity assay. The results demonstrated that RES was successfully complexed with STE and HP-β-CD, and the crystalline state of RES was changed after the complexation. The water solubility of RES increased about 30 times, and the saturated solubility of the complexes prepared by jet milling reached the highest of 993.32 μg/mL. Meanwhile, RES could interact with STE through hydrogen bonding, and also could be probably inserted into the cavities of HP-β-CD. Moreover, the complexes prepared by different methods possessed good antioxidant activity and did not exhibit significant cytotoxicity. In conclusion, STE&HP-β-CD can effectively solubilize RES, and solid-phase preparation technologies (e.g., jet milling) have the potential to prepare water-soluble complexes. The complex powders can be used as raw materials for nutraceuticals or pharmaceuticals.
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