Abstract
In this study, we developed a one step process to synthesize nanogel containing silver nanoparticles involving electron beam irradiation. Water-soluble silver nitrate powder is dissolved in the distilled water and then poly(acrylic acid) (PAAc) and hexane are put into this silver nitrate solution. These samples are irradiated by an electron beam to make the PAAc nanogels containing silver nanoparticles (Ag/PAAc nanogels). The nanoparticles were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In addition, the particle size and zeta-potential were confirmed by a particle size analyzer (PSA). The antibacterial properties of the nanogels were evaluated by paper diffusion test. The Ag/PAAc nanogels had an antibacterial effect against Escherichia coli and Staphylococcus aureus. The nanogels also demonstrated a good healing effect against diabetic ulcer. The size of the Ag/PAAc nanogels decreased with increasing irradiation doses, and the absolute value of the zeta potential increased with increasing irradiation doses. Also, the Ag/PAAc nanogels exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria. In in vivo wound healing, the Ag/PAAc nanogels have a good healing effect.
Highlights
IntroductionAre considered to be a distinct type of macromolecule, compared to linear and branched polymers or macroscopic gels [2]
Nanogels are internally cross-linked particles of sub-micrometer size made of hydrophilic polymers [1]and are considered to be a distinct type of macromolecule, compared to linear and branched polymers or macroscopic gels [2]
The main goal of this study is to develop a one step process to synthesize nanogels containing silver nanoparticles involving electron beam irradiation
Summary
Are considered to be a distinct type of macromolecule, compared to linear and branched polymers or macroscopic gels [2]. Such structures, along with their bigger analogues—microgels—are tested for a number of practical applications, starting from fillers in a coating industry to “smart” drug delivery systems [3]. One method is physical crosslinking, such as hydrogen bonds, crystallized domains, hydrophobic interactions and temperature-induced sol-gel transition. These physically crosslinked gels can reversibly degrade into the corresponding precursors upon external stimuli. Radiation technology was used for the nanogel preparation, as this method is capable of sterilization and crosslinking concurrently without a catalyst
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