Abstract
BackgroundTwo months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients.MethodsThe clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China.ResultsIn total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively.ConclusionsSome patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation.Trial registrationCurrent Controlled Trials ChiCTR2000033580, Jun 6th 2020. Retrospectively registered.
Highlights
Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients
Few studies have described positive reverse transcriptase–polymerase chain reaction (RT-PCR) test results in patients who have recovered from COVID-19 [3,4,5], and the clinical characteristics of the recovered COVID-19 patients with recurrent positive RT-PCR results remain unclear
Epidemiological characteristics As of March 15, 2020, clinical data had been collected from 758 patients with laboratory-confirmed COVID-19 who were quarantined at rehabilitation stations in Huangpi, Wuhan, Hubei Province
Summary
Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients. Coronavirus disease 2019 (COVID-19) is an emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in early December 2019 in Wuhan, China. The patients suspected of having COVID-19 were diagnosed by positive RT-PCR for SARS-CoV-2, and 2 consecutively negative RT-PCR results were used as a criterion for hospital discharge. Few studies have described positive RT-PCR test results in patients who have recovered from COVID-19 [3,4,5], and the clinical characteristics of the recovered COVID-19 patients with recurrent positive RT-PCR results remain unclear. We studied the characteristics of recovered COVID-19 patients with recurrent positive RT-PCR results for SARS-CoV-2 in Huangpi, Wuhan
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
