Abstract
Background. Primary cutaneous T-cell lymphomas (CTCLs) are a group of extranodal non-Hodgkin lymphomas that may be present in the skin without any evidence of extracutaneous disease. The aim of this study was to evaluate the epidemiological characteristics of primary CTCL in Isfahan, Iran. Method. A total of 95 patients who were diagnosed as having primary CTCL were recruited during a 10-year period (2003–2013) and were classified according to the new WHO-EORTC criteria. Results. The patient group consisted of 43 (44.8%) males and 53 (55.2%) females, which indicated a female predominance (M : F ratio 1 : 1.2). The mean age at the time of diagnosis was 41.78 ± 16.88 years (range: 7–84 years). Prior to diagnosis, the lesions had persisted for a mean of 8.34 ± 4.38 years (range: 0–55 years). The age at peak diagnosis was 20–40 years (43%). The most frequent subtypes were mycosis fungoides (MF) (88.5%). Four patients died from CTCL-related complications. Conclusions. The distinguishing epidemiologic characteristics of primary CTCL, particularly those MF, in Iran, are the absence of a male predominance and lower age at diagnosis. This is likely because of the characteristic ethnic group diversity and increased susceptibility among younger population.
Highlights
Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of lymphomas that may be present in the skin without any evidence of extracutaneous disease at the time of diagnosis [1, 2]
Between the years 2003 and 2013, a total of 95 cases of primary CTCLs were diagnosed in the Cutaneous Lymphoma Center of the Dermatology Department of the Isfahan University of Medical Sciences, Iran
The mean age at the time of diagnosis was 41.7 ± 16.9 years and the lesion had persisted for a mean of 4.4 ± 8.3 years before the diagnosis was made (Table 1)
Summary
Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of lymphomas that may be present in the skin without any evidence of extracutaneous disease at the time of diagnosis [1, 2]. Primary cutaneous T-cell lymphomas (CTCLs) are a group of extranodal non-Hodgkin lymphomas that may be present in the skin without any evidence of extracutaneous disease. The distinguishing epidemiologic characteristics of primary CTCL, those MF, in Iran, are the absence of a male predominance and lower age at diagnosis. This is likely because of the characteristic ethnic group diversity and increased susceptibility among younger population
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