Abstract
Aim To investigate the metabolic profiles of newly diagnosed type 2 diabetes (NEW2D) in Chinese older adults (≥65 years) and assess the proportion of patients who achieved the targeted goals of blood glucose, blood pressure, and blood lipid. Methods NEW2D study was an observational, longitudinal, prospective cohort study involving patients who were diagnosed with type 2 diabetes (T2D) within the past 6 months and had a follow-up of 12 months. Participants were divided into younger NEW2D group (aged 20-65 years old) and older NEW2D group (aged ≥65 years old) according to age of diabetes onset. The baseline metabolic profiles were compared and the proportion of patients achieving adequate control of blood glucose, blood pressure, and blood lipids in reference to target goals were assessed during treatment. Results The older NEW2D (n = 1362) had a lower BMI, HbA1c%, diastolic blood pressure, triglyceride, low-density lipoprotein cholesterol (LDL-C), and total cholesterol, higher systolic blood pressure, and high-density lipoprotein cholesterol levels at baseline. 47.8%, 66.7%, and 39.4% reached the target of HbA1c < 7.0%, BP < 140/90 mmHg, and LDL − C < 2.6 mmol/L, respectively. After 12 months, the proportion achieving above three targets increased to 70.2%, 76.1%, and 47.5%, respectively. The proportions of patients achieving three combined therapeutic targets doubled from 13.5% to 26.7%. Conclusion The older NEW2D patients have special metabolic profiles compared with younger patients. The control of cardiovascular disease risk factors was suboptimal in older adults with type 2 diabetes.
Highlights
Diabetes, type 2 diabetes (T2D), is becoming more prevalent in the general population, especially in older people [1]
Evaluating the current control of Journal of Diabetes Research glycemia, blood pressure, and lipid in older people with newly diagnosed type 2 diabetes (NEW2D) in China will promote a better management of risk factors of cardiovascular disease (CVD) in the future
Characteristics of Older NEW2D Participants. 38.6%, 25.8%, and 35.5% of the older NEW2D patients were from tier 1, tier 2, and tier 3 hospitals, respectively, of which the pattern distribution was different from that in younger diabetes group (p < 0:0001)
Summary
Type 2 diabetes (T2D), is becoming more prevalent in the general population, especially in older people [1]. The estimated prevalence of newly diagnosed diabetes in older people was 14.2% to 15.5%, making the development of therapeutic strategies targeted to this broad population of patients challenging [3]. Hypertension, and dyslipidemia, which often coexist in older people, have been shown to increase the risk of cardiovascular disease (CVD) and mortality [4, 5]. Evaluating the current control of Journal of Diabetes Research glycemia, blood pressure, and lipid in older people with newly diagnosed type 2 diabetes (NEW2D) in China will promote a better management of risk factors of CVD in the future
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