Abstract
Background: Systemic lupus erythematosus (SLE) admission can cause considerable morbidity, mortality and healthcare utilization. SLE generally develops in younger patients who are in their most productive years. That said, it is pivotal to determine predictors for poor outcomes (disability and mortality) from SLE hospitalization especially among highly developing Asian countries like Malaysia. Methods: Our retrospective cross-sectional study involved adults aged 12 years and above with underlying SLE who were admitted to the medical ward of our hospital between January 2018-December 2018. Results: This study demonstrated that infection and lupus flare are the main causes of hospitalization. Nearly one-fifth (18.9%) of lupus hospitalization had poor outcomes. Multivariate logistic regression analysis revealed that high disease activity (OR=1.15, 95% CI 1.05-1.47, p=0.001) and concurrent flare with infection (OR=1.10, 95% CI 1.02-1.53, p=0.007) at hospitalization were remarkably associated with poor outcome at discharge. Conclusion: Optimization of disease activity and infection control during outpatient’s visits is crucial to improve hospitalization outcome.
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