CHARACTERISTICS NONSPECIFIC ELEMENT IMMUNITY IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS

Abstract

Background: Investigate characteristics non-specific immunity in the blood in patients with chronic gastritis and chronic atrophic gastric. Materials and methods: The study involved 200 patients aged 25 to 65 who were in randomly into 3 groups. The first group included 100 healthy subjects in the second group – 85 patients with moderate atrophic gastritis, gastric body, the third group – 25 patients with severe atrophic gastritis of the body of the stomach. The study was conducted with the approval of the Ethics Committee FGBNU “Institute of Medical Problems of the North” (Acting Director – MD, professor Kasparov E.V.). Each participant signed an informed consent form for examination, according to the Declaration of Helsinki of the World Medical Association, which regulates conduct research. Diagnosis of atrophic gastritis performed by determining the pepsinogen-1, 2-pepsinogen and H. pylori antibodies in serum and morphological study of the gastric mucosa. Evaluation of non-specific immunity was conducted by studying the chemiluminescent activity of neutrophils (De sole p.et al.; 1983). Statistical analysis was performed using the application package Statistica 7.0 (StatSoft, USA). Results: violation of spontaneous and induced functional activity of neutrophils observed in all groups of patients with chronic gastritis, while in patients with chronic superficial gastritis revealed a reduction in both spontaneous and induced chemiluminescence activity of neutrophils. On the other side of the milestones of patients with chronic atrophic gastritis there is an increase of the functional activity of neutrophils expressed significantly more severe atrophic changes in the gastric mucosa. Considering that the main function of neutrophil granulocytes – phagocytosis of bacterial agents, modified own cells, their increased activity can be attributed to an infectious process in the gastric mucosa and harsh destruction of cells of the stomach due to atrophic changes. Conclusion: thus, with an increase in infectious load or atrophic changes in the mucosa of the stomach does not exclude the exhaustion of reserve capacity of phagocytes, their modification, thus the transformation of precancerous condition in cancer.