Abstract
We have investigated the activation of pristanic acid to its CoA-ester in rat liver. The results show that peroxisomcs, mitochondria as well as microsomes contain pristanoyl-CoA synthetase activity. On the basis of competition experiments and immunoprecipitation studies using antibodies raised against rat liver microsomal long-chain fatty acyl-CoA synthetase (EC 6.2.1.3) we conclude that pristanic acid is activated by the same enzyme which activates long-chain fatty acids i.c., long-chain fatty acyl-CoA synthetase.
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