Characteristics and evolution of pre-diabetes

Abstract

In this study, a total of 2344 middle-aged or aged adults living in Beijing who underwent 75 g oral glucose tolerance test (OGTT)were followed up for about 4 years. It showed that isolated-impaired fasting glucose (I-IFG) had severe hepatic insulin resistance and basal islet beta cell dysfunction. Isolatedimpaired glucose tolerance (I-IGT) had marked peripheral insulin resistance and severe after-glucose-loading beta cell dysfunction. The improvement of glucose regulation was in good accordance with the improvement of insulin resistance and pancreatic beta-cell function. Those with less metabolic abnormalities at baseline and with more obvious improvement would be more likely to revert to and maintain normal glucose tolerance. The intensive integrated intervention could significantly decrease the conversion rate of impaired glucose regulation (IGR) to diabetes mellitus, and the effect was better than single drug intervention. The increase of waist circumference or systolic blood pressure, the deterioration of islet β cell function were the influencing factors of the conversion of IGR to diabetes mellitus. Key words: Impaired fasting glucose; Impaired glucose tolerance; Insulin resistance; Islet β cell function; Evolution