Characteristics and distribution of impaired glucose regulation subjects in Gansu province

Abstract

Objective To analysis the characteristics and distribution of impaired glucose regulation (IGR) in Gansu province. Methods We selected 28 087 participants who were 20-74 years old in diabetes epidemiology survey between 2013 and 2014 in Gansu province which enrolled 31 417 participants and then divided them into 4 groups by blood glucose level after the 75 g oral glucose tolerance test (OGTT) according to the 1999 WHO diabetes diagnostic criteria: normal glucose tolerance (NGT), isolated impaired fasting glucose (I-IFG) and isolated impaired glucose tolerance (I-IGT) groups, combined IFG and IGT (IFG/IGT) groups. Then we analyzed the distribution of IGR between city and countryside, different gender and age groups and risk factors of IFG and IGT. Comparison between two groups was done within independent samplet test and chi- square test. Results The prevalence of I- IFG and I- IGT in countryside was higher than in the city, the difference was statistically significant (4.4% (641/14 480) vs 2.7% (464/16 937) and 10.0% (1443/14 480) vs 9.3%(1571/16 937), χ2=65.5 and 4.3, respectively,P<0.05). In rural area, the prevalence of I- IFG was higher in men than in women, the difference was statistically significant (4.8% (310/6 417) vs 4.1% (331/8 063), χ2=4.4,P<0.05). In urban area, the prevalence of I-IGT was higher in men than in women, the difference was statistically significant (10.0% (765/7 666) vs 8.7% (806/9 271), χ2=8.2,P<0.05). The prevalence of I-IGT and IFG/IGT increased with age. The prevalence of I-IGT among different age groups was 5.99%, 8.33%, 9.80%, 10.22% and 12.28%, the differences between 20 and 30,30 and 40, 50 and 60 group were statistically significant(χ2=20.95, 8.0 and 14.0,P<0. 05 all above). The prevalence of IFG/IGT among different age groups was 0.67%,1.02%,1.98%,2.51% and 3.44%.The differences between adjacent groups above 30 years old were statistically significant (χ2=18.2, 4.5 and 9.8, P<0. 05 all above). The risk factors for IFG were male, the old age, family history of diabetes, overweight and rural residents (OR=1.13, 1.16, 1.30, 1.15, 1.52,P <0.05 all above); the risk factors for IGT were the old age, drinking, overweight, general obesity and central obesity(OR=1.18, 1.17, 1.27, 1.44, 1.08,P <0.05 all above). Conclusions The characteristics and distribution of IGR between different gender, different age groups and different areas (city or countryside) were significantly different. It is helpful to pay attention to IGR and control risk factors to reduce the incidence of diabetes. Key words: Impaired glucose regulation; Impaired fasting glucose; Impaired glucose tolerance; Epidemiological survey