Abstract
Hongyuan Yan and Kyung Ho Row* Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon, 402–751, Korea * Corresponding author. E-mail: rowkho@inha.ac.kr Received: 12 April 2006 / Accepted: 27 June 2006 / Published: 29 June 2006 Abstract: Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity to the predetermined molecule (template) are now seeing a fast growing research. However, optimization of the imprinted products is difficult due to the fact that there are many variables to consider, some or all of which can potentially impact upon the chemical, morphological and molecular recognition properties of the imprinted materials. This review present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. The synthesis, characteristic, effect of molecular recognition and different preparation methods of MIP in recent few years are discussed in this review, unsolved problems and possible developments of MIP were also been briefly discussed. Keywords: molecularly imprinted polymer, special molecular recognition, synthetic approach 1. Molecular Imprinting Technology Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1-3]. Synthesis of MIP is a relatively straightforward and inexpensive procedure. In short, the molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent. Subsequently, this pre-polymerization mixture is irradiated with UV light or
Highlights
Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1,2,3]
The molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent
As a technique for the creation of artificial receptor-like binding sites with a ‘memory’ for the shape and functional group positions of the template molecule, molecular imprinting has become increasingly attractive in many fields of chemistry and biology, as an affinity material for sensors [7,8,9,10,11], binding assays [12], artificial antibodies [13,14], adsorbents for solid phase extraction [15,16,17,18,19], and chromatographic stationary phases [20,21,22,23]
Summary
Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1,2,3]. The molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent. This pre-polymerization mixture is irradiated with UV light or. The complexes formed between the template molecule and the functional monomers will be stabilized within the resulting rigid, highly cross-linked polymer. MIP possess several advantages over their biological counterparts including low cost, ease of preparation, storage stability, repeated operations without loss of activity, high mechanical strength, durability to heat and pressure, and applicability in harsh chemical media. As a technique for the creation of artificial receptor-like binding sites with a ‘memory’ for the shape and functional group positions of the template molecule, molecular imprinting has become increasingly attractive in many fields of chemistry and biology, as an affinity material for sensors [7,8,9,10,11], binding assays [12], artificial antibodies [13,14], adsorbents for solid phase extraction [15,16,17,18,19], and chromatographic stationary phases [20,21,22,23]
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