Abstract
Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity tothe predetermined molecule (template) are now seeing a fast growing research. However,optimization of the imprinted products is difficult due to the fact that there are manyvariables to consider, some or all of which can potentially impact upon the chemical,morphological and molecular recognition properties of the imprinted materials. This reviewpresent a summary of the principal synthetic considerations pertaining to good practice in thepolymerization aspects of molecular imprinting, and is primarily aimed at researcher familiarwith molecular imprinting methods but with little or no prior experience in polymersynthesis. The synthesis, characteristic, effect of molecular recognition and differentpreparation methods of MIP in recent few years are discussed in this review, unsolvedproblems and possible developments of MIP were also been briefly discussed.
Highlights
Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1,2,3]
The molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent
As a technique for the creation of artificial receptor-like binding sites with a ‘memory’ for the shape and functional group positions of the template molecule, molecular imprinting has become increasingly attractive in many fields of chemistry and biology, as an affinity material for sensors [7,8,9,10,11], binding assays [12], artificial antibodies [13,14], adsorbents for solid phase extraction [15,16,17,18,19], and chromatographic stationary phases [20,21,22,23]
Summary
Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1,2,3]. The molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent. This pre-polymerization mixture is irradiated with UV light or. The complexes formed between the template molecule and the functional monomers will be stabilized within the resulting rigid, highly cross-linked polymer. MIP possess several advantages over their biological counterparts including low cost, ease of preparation, storage stability, repeated operations without loss of activity, high mechanical strength, durability to heat and pressure, and applicability in harsh chemical media. As a technique for the creation of artificial receptor-like binding sites with a ‘memory’ for the shape and functional group positions of the template molecule, molecular imprinting has become increasingly attractive in many fields of chemistry and biology, as an affinity material for sensors [7,8,9,10,11], binding assays [12], artificial antibodies [13,14], adsorbents for solid phase extraction [15,16,17,18,19], and chromatographic stationary phases [20,21,22,23]
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