Abstract
The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.
Highlights
The World Health Organization estimates that between 200 and 300 million people worldwide are infected with Schistosoma spp and 800 million people in the world are at risk of infection
Worm recovery was carried out as per the technique prescribed by Pellegrino and Siqueira.[3]. Experiments were performed on a 7T magnetic resonance scanner (MRI System 7T/210 ASR Horizontal Bore Magnet, Agilent Technologies, Palo Alto, CA, USA)
Serial 4 μm sections from all paraffin blocks were stained with haematoxylin and eosin (H&E)
Summary
The World Health Organization estimates that between 200 and 300 million people worldwide are infected with Schistosoma spp and 800 million people in the world are at risk of infection. The authors[2] concomitantly provided the first histopathological documentation of such lesions, identified as choroidal granulomas containing Schistosoma mansoni eggs. We infected 25 male mice (Mus musculus – Swiss Webster, weighing between 18 and 20 grams) with 50 LE strain cercariae subcutaneously and 25 animals were maintained as controls (uninfected).
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