Abstract
Summary1. Tissue extracts from mice of the high-leukemia strain Ak injected into newborn mice greatly increased the leukemia incidence in Rf, DBA 1 and C3Heb mice. and greatly hastened the development of leukemia in AkR mice. 2. Mortality without gross anatomic manifestation of leukemia was also enhanced in extract-injected mice of low-leukemia strains. 3. Although all leukemias in Ak mice were lymphoid with thymic involvement, many leukemias in the low-leukemia strains were of non-thymic types. 4. Transplantation assays of leukemias induced in the low-leukemia strains disclosed a heterogeneity in types, some being related immunogenetically with both host and donor strain. 5. Neither salivary gland nor other tumors were induced by the leukemia agent studied. 6. The available information suggests consideration of a process analogous with DNA-induced transformation (transduction) of genetic properties of microorganisms rather than to a natural type of viral infection.
Published Version
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