Abstract

Abundant evidence from family, adoption, and twin studies point to large genetic contributions to individual differences in vulnerability to develop dependence on addictive substances. Twin data suggest that much of this genetic vulnerability is shared by individuals who are dependent on a variety of addictive substances, though some are likely to be substance-specific. Twin data for abilities to quit smoking provide some of the best evidence for genetic influences on abilities to achieve and maintain abstinence from use of an addictive substance.

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