Abstract
Abstract Elasticity is one of the crucial parameters for the functioning of biological membranes. This chapter focuses on the coupling of lipid membrane properties, such as spontaneous curvature, bending rigidity, and Gaussian modulus of curvature to ion-channel activity. For this purpose, current theories of coupling mechanisms, such as the lateral pressure concept and hydrophobic matching, are reviewed and discussed. A brief tutorial on the experimental determination of membrane elastic parameters is presented, focusing mainly on X-ray scattering in combination with osmotic stress. Finally, the theory is applied on funnel-shaped and hourglass-shaped ion channels in the context of enzymatic hydrolysis of sphingomyelin, using experimental data.
Published Version
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