Abstract
Escape from host immunosurveillance is essential to development and establishment of cancer in a patient. Cancer recruits various types of dysregulated immune cells which form tumor microenvironment and contribute to cancer-associated immune suppression. Such immune cells comprise tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences has showed that MDSCs play pivotal roles among these tumor-protector cells in multiple steps of cancer progression. MDSCs are immature myeloid cells and suppress adaptive immunities by inhibiting the cytotoxic functions of T cells, NK cells, dendritic cells and so forth. In clinical settings, number of circulating MDSCs predicts worse prognosis and response to treatment. Therefore, targeting MDSCs could be promising treatment option for patient with cancer. This chapter briefly summarizes the recruitment mechanisms and tumor-supportive functions of MDSCs, and the potential strategies to target MDSCs in cancer.
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