Abstract
This chapter discusses the adenoviruses. The Adenovirus group is a large and widespread family of viruses infecting many species of the animal world. At the present time about 50 distinct antigenic types are known which can be isolated from man, monkeys, cattle, mice and dogs, and there is every reason to assume that this list is far from complete. With a few exceptions, members of this group do not produce overt disease in small laboratory animals and their discovery was thus delayed until the advent of tissue culture techniques. Finally, Adenovirus types 1, 2, 4, 5 and 6, but not type 3, produces an inhibitor which is type-specific and which reduces the production of Adenovirus type 5, Poliovirus type 1, and vaccinia virus in tissue cultures. It does not affect the adsorption of virus to the cells but rather, it reduces the number of cells producing virus. The Adenoviruses are classified principally on the basis of serological tests showing antigenic individuality. For the identification purposes, they are also divided into species groups, human, simian, mouse, etc. according to the animal from which they were isolated. The two major characteristics of illness because of Adenovirus infection are pharyngitis and regional lymph gland enlargement.
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