Abstract
Cancer immunotherapy has improved the clinical outcomes of cancer treatment. In the context of immunotherapy, traditional chemotherapy also sees a new opportunity as a companion treatment. However, their optimal and safe delivery remains a challenge due to the systemic adverse effects. Local drug delivery systems can help reduce the systemic toxicity of immunotherapy by confining the immunostimulatory effects on tumors. Introducing immunoactive biomaterials and combinations of supporting agents, drug delivery systems further enhance the efficacy of local antitumor immunity and enable its translation to systemic effects against metastatic tumors. This chapter summarizes different types of cancer immunotherapy and introduces various drug delivery systems used for their local delivery, focusing on intervention therapies using immunostimulators and chemotherapy. We discuss the rationales, outcomes, and remaining challenges of current delivery approaches.
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