Abstract

This chapter explains normal adrenocortical function and provides an overview of related disorders, including: hypercortisolemia, Cushing’s syndrome, hypocortisolemia, Addison’s disease, congenital adrenal hyperplasia, Nelson’s syndrome and adrenocortical insufficiency. For each immunoassay analyte commonly used in the adrenocortical field the biological function is explained, with the clinical applications of the test and its limitations, including test protocols. Typical assay technology is described. The type of sample and frequency of use are included, with an example reference interval (for background information only). The analytes included are cortisol and adrenocorticotropic hormone. In the final section, management of patients with Cushing's syndrome is described.

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