Abstract

Using microcapsules for medical and technical purposes relies on capsule properties such as stability, shape, and permeability, which depend on the production process and the capsule material itself. The methods presented here, which are based on nuclear magnetic resonance microscopy, allow one to quantitatively determine these parameters for individual microcapsules with or without coatings. The experiments are noninvasive and can access such parameters as geometry, diffusion constants, or molecular correlation times in different chemical environments with a spatial resolution of ~10μm. The influence of production parameters as well as the dynamic behavior of capsules in various test environments are characterized for potential applications in targeted drug delivery.

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