Abstract
Antibiotics under the groups of aminoglycoside (AG), tetracycline and macrolides (MLs) have been extensively used in veterinary practise not only for treatment but also as growth promoters since long and thus it has caused a concomitant rise in resistance to these drugs in animal pathogens. Furthermore, rising resistance to these groups of drugs in human pathogens has also been linked to prolonged, indiscriminate and extensive use in animal husbandry. Pathogens with simultaneous resistance to AGs, tetracycline and MLs along with other drugs like β-lactams, carbapenems, fluoroquinolones and even with biocides are not uncommon because of the presence of multiple resistance determinants in a plasmid, mobile genetic elements or transposons. This chapter deliberated with the mechanism of resistance against AG, tetracycline and ML, its current status in animals, laboratory protocols to detect such resistance and on what should be the therapeutic strategy in dealing with such pathogens.
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