Abstract
Polymeric micelles formed from single copolymers often lack stability, exhibit unsatisfactory drug loading capacity, or have broad size distribution, primarily due to limitations in the number of available building blocks. Conversely, the mixed micellar nanocarriers offer significant improvements with regards to carrier stability and improved drug entrapment efficacy. A mixed micellar formulation would enable incorporation of active targeting moieties, e.g., stimuli-responsive drug release or polymers influencing drug penetration through biological barriers. Furthermore, the mixed micelles systems may easily be optimized regarding size and surface charge as well as release rate of active agent. Mixed micellar formulations showed improved efficacy in the fields of anticancer therapeutics and improved oral delivery of poorly water-soluble agents. This chapter aims to discuss and review the recent developments and future perspectives in the field of mixed micellar drug delivery systems.
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