Abstract
The gastrointestinal system is composed of a network of the immune cell population, responsible for maintaining tissue homeostasis. In recent years, studies related to disruption of tissue-specific immune cell function have emphasized the deregulation of tissue homeostasis directly related to several gastrointestinal diseases. Macrophages are cells of the innate immune response and may be resident in the intestine, endowed with specific markers and functions, being responsible for the maintenance of homeostasis, therefore, changes in these cells may trigger abnormalities associated with inflammation, cancer, and autoimmune diseases. This chapter reviews the main markers and features of the macrophages residing in the intestine, as well as the crosstalk between these cells and the intestinal microenvironment. Understanding how tissue-specific signals can influence the activation, polarization, and inflammatory profile of these cells may aid how macrophages participate in triggering diseases and consequently open potential avenues to treat inflammatory disorders.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
