Abstract
The chapter describes the role of enzyme hepatitis B virus (HBV) polymerase as a target for development of anti-HBV drugs. Introduction gives a brief background about epidemiology of HBV. Structure and genome of HBV are described. The mechanism of replication of the virus is presented. Current treatment of HBV is outlined. Multiple roles of the enzyme HBV polymerase in replication of the virus are elaborated. Multiple domains in the structure of HBV polymerase are described. Mutations are so common in HBV. Locations of drug-resistant mutations have been identified. Structures of various synthetic drugs active against HBV are presented. Evolved model for inhibition of HBV DNA polymerase has been discussed. Need for new anti-HBV drugs and possible sites of action have been commented. Some medicinal plants exhibiting anti-HBV action have been indicated. Reference has been made to all clinical trials related to anti-HBV drugs and sites of action for new drugs have been tabulated with relevant references. Future events in development of anti-HBV drugs are outlined.
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